body logo dositest

History

This project was initially funded by the Région Pays de Loire and Cancéropôle Grand Ouest. This allowed funding for the Post Doctoral stay of Erin McKay, who designed the first version of TestDose. The preliminary phase of DosiTest was conducted by Ludovic Ferrer, as part of his PhD work (presented 24/10/2011). This initial work led to the proof of concept of DosiTestFerrer L, McKay E, Lisbona A, Kraeber-Bodéré F, Bardiès M 2009. DosiTest : Accuracy of radio-immunotherapy dosimetry protocol J Nucl Med 50(Supp 2): 392p. A 18 month project was funded thanks to the first national call “PhysiCancer” in 2011: Research Proposal in Physics, Mathematics and Engineering Sciences Applied to the Cancer Research. This beta phase of DosiTest, included 4 clinical centres (CHU Toulouse, etc…) as part of a consortium that associated INSERM and IRIT.
  • During the project, Marie-Paule Garcia contributed to the development of TestDose, a tool designed to generate scintigraphy images and perform absorbed dose calculation.
  • The clinical situation of 177Lu-DOTATATE was selected and a “realistic-enough” pharmacokinetics based on the literature was defined during Daphnée Villoing’s PhD. She also generated the Monte Carlo-based reference dosimetry.
The conclusions were that, even though the simulation of complex patient datasets were feasible, a major limit was the difficulty to generate images that could be integrated in clinical workstations “as if it was a real patient“: most vendor-specific systems use proprietary tags that prevent the integration of “foreign” images.
  • Further work performed by Gustavo Costa (planar image modelling), and more recently by Gunjan Kayal (SPECT/CT image modelling), to address these issues.
  • Maxime Chauvin participated in the definition of Planar and SPECT (Circular/Non Circular Orbit) acquisition mode modelling, and helped tremendously in the computing architecture of DosiTest.
Various anthropomorphic models ware considered during the project:
  • Initially, NCAT was considered for the first simulations. In parallel, voxel-based reference models such as those presented in ICRP report 110 were considered to validate reference absorbed dose calculation with MCNPX and GATE.
  • As preliminary results led to “too good to be true” results, we decided to consider real patient geometry for DosiTest. A series of patient acquisitions (CT) was selected to define the geometry of the virtual patient.

Current status of DosiTest

  • A full dataset of simulated SPECT images was generated within the IAEA Coordinated Research Project (CRP) on “Dosimetry in Radiopharmaceutical therapy for personalized patient treatment” (E2.30.05), and the dosimetry analysis is being performed by CRP participants.
  • Clinical centres have been selected and clinical images are being simulated according to their requirements/equipment.
  • Preliminary results of DosiTest should be available by the end of 2021/early 2022.

Acknowledgements

This work was partially supported by different grants and funding bodies, over a range or research projects that contributed all to the development of DosiTest:

  • Brazilian National Council of Technological and Scientific Development (CNPq)
  • HLT11-REG2 MetroMRT EMRP Research (Grant 2013–2015)
  • 15HLT06 MRTDosimetry (Grant 2016-2019)
  • CALMIP supercomputing centre allocation 2016-P19001
  • Medirad project (Euratom research and training Work programme 2014-2018 under grant agreement No. 755523).
  • ENEN + project (Euratom research and training Work programme 2016-2017-1 #75576).
  • IAEA Coordinated Research Project (CRP) on “Dosimetry in Radiopharmaceutical therapy for personalized patient treatment” (E2.30.05)16

Publications related to the project

Kayal G, Chauvin M, Vergara-Gil A, Clayton N, Ferrer L, Moalosi T, Knoll P, Struelens L, Bardiès M (2021) “Generation of clinical 177Lu SPECT/CT images based on Monte Carlo simulation with GATE”. Physica Medica 85 24-31. doi: 10.1016/j.ejmp.2021.04.002.

Costa G C A, Bonifacio D A B, Sarrut D, Cajgfinger T and Bardiès M (2017) “Optimization of GATE simulations for whole-body planar scintigraphic acquisitions using the XCAT male phantom with (177)Lu-DOTATATE biokinetics in a Siemens Symbia T2”. Physica Medica 42 292-297

Villoing D, Marcatili S, Garcia MP, Bardiès M (2017) “Internal dosimetry with the Monte Carlo code GATE: validation using the ICRP/ICRU female reference computational model”. Physics in Medicine and Biology 62 1885-1904

Garcia MP, Bert J, Benoit D, Bardiès M and Visvikis D (2016) “Accelerated GPU based SPECT Monte Carlo simulations”. Physics in Medicine and Biology 61 4001-4018

Garcia MP, Villoing D, McKay E, Ferrer L, Cremonesi M, Botta F, Ferrari M, Bardiès M (2015) “TestDose: A nuclear medicine software based on Monte Carlo modeling for generating gamma camera acquisitions and dosimetry”. Medical Physics 42(12) 6885-6894

Marcatili S, Villoing D, Mauxion T, McParland B J and Bardiès M (2015) “Model-based versus specific dosimetry in diagnostic context: comparison of three dosimetric approaches”. Medical Physics 42 1288-1296

Kayal G, Chauvin M, Vergara-Gil A, Clayton N, Ferrer L, Moalosi T, Knoll P, Struelens L, Bardiès M, Generation of clinical 177Lu SPECT/CT images for dosimetry in Molecular Radiotherapy based on Monte Carlo simulation with GATE, Journal of Nuclear Medicine 62(Supp 1):1587, 2021

Kayal G, Chauvin M, Vergara-Gil A, Clayton N, Struelens L, Bardiès M, Generation of realistic SPECT/CT images for Lu dosimetry in Molecular Radiotherapy (MRT) based on Monte Carlo simulation with GATE, European Association of Nuclear Medicine 2020 Virtual. Eur J Nucl Med Mol Imaging 47, 1–753 (2020). https://doi.org/10.1007/s00259-020-04988-4

Kayal G, Chauvin M, Mora-Ramirez E, Struelens L, Bardiès M, Implementation of SPECT auto-contouring detector motion in GATE Monte Carlo simulation for 177Lu and 131I Molecular Radiotherapy (MRT) dosimetry, European Association of Nuclear Medicine 2020 Virtual. Eur J Nucl Med Mol Imaging 47, 1–753 (2020). https://doi.org/10.1007/s00259-020-04988-4

Garcia MP, Bert J, Villoing D, Reilhac A, Grégoire MC, Visvikis D and Bardiès M (2014) “Hybrid CPU/GPU SPECT Monte Carlo Simulations: The Hexagonal Hole Collimator Case”. IEEE Nuclear Science Symposium & Medical Imaging Conference (NSS/MIC), Seattle, WA USA, 8-15 November 2014

Garcia MP, Der Sarkissian H, McKay E, Ferrer L, Bardiès M, Villoing D, Batatia H, Basarab A, Tourneret JY, Kouamé D (2013) “TestDose : A SPECT image generator for clinical dosimetry studies” Proceedings of SPIE Medical Imaging Volume 8668 Medical Imaging 2013: Physics of Medical Imaging, 86684V (March 6, 2013); doi:10.1117/12.2007840

Garcia MP, Villoing D, McKay E, Ferrer L, Der Sarkissian H, Poirot M, Bardiès M (2013) “Generation of Whole-Body Scintigraphic Images with New GATE Output Capacities” IEEE NSS-MIC Conference Record, 2013

Ferrer L, McKay E, Lisbona A, Kraeber-Bodéré F, Bardiès M (2009) “DosiTest : Accuracy of radio-immunotherapy dosimetry protocol”. Journal of Nuclear Medicine 50(Supp 2): 392p.

McKay E, Ferrer L, Barbet J, Bardiès M (2009) “TestDose : Software for creating dosimetry problems”. Journal of Nuclear Medicine 50(Supp 2): 392p

Kayal G, Chauvin M, Vergara-Gil A, Clayton N, Ferrer L, Moalosi T, Knoll P, Struelens L, Bardiès M, Generating clinical SPECT images for dosimetry in Molecular Radiotherapy with GATE Monte Carlo simulation, BHPA Belgium 2021, 2021 (Virtual)

Kayal G, Chauvin M, Vergara-Gil A, Clayton N, Moalosi T, Knoll P, Struelens L, Bardiès M, DosiTest: Generation of simulated datasets for patient-specific dosimetry in molecular radiotherapy, 59èmes Journées Scientifiques de la SFPM, Rennes 2021

Kayal G, Chauvin M, Vergara-Gil A, Clayton N, Ferrer L, Moalosi T, Knoll P, Struelens L, Bardiès M, Generation of realistic patient-specific SPECT images with GATE Monte Carlo simulation for 177Lu dosimetry in Molecular Radiotherapy (MRT), ECMP, Italy, 2021

Kayal G, Chauvin M, Mora-Ramirez E, Tran-Gia J, Lassman M, Calvert N, Tipping J, The MRT Dosimetry Collaboration, Struelens L, Bardiès M, Implementation of SPECT auto-contouring detector motion in GATE Monte Carlo simulation for 177Lu and 131I Molecular Radiotherapy (MRT) dosimetry, ECMP Italy, 2021

Kayal G, Chauvin M, Struelens L, Bardiès M. Modeling SPECT auto-contouring acquisition for 177Lu Molecular Radiotherapy (MRT) using new developments in GATE. MCMA International Conference held in Montreal, Canada, 2019.

Kayal G, Chauvin M, Struelens L, Bardiès M. Monte Carlo Simulation of SPECT Imaging. European Workshop on The Clinical Implementation of Dosimetry For Molecular Radiotherapy held in NPL, UK 2019.

Garcia MP, Villoing D, McKay E, Ferrer L, Poirot M, Bardiès M (2013) “Efficient generation of SPECT images using compartmental modelling”. Geant4 2013 International User Conference, 7-9 October 2013, Bordeaux, France

Contact Us